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Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake

It works by mimicking hormones that help regulate blood sugar levels and slow how quickly food moves through the digestive tract, which can reduce appetite and caloric intake

Peak weight loss acceleration occurs during the dose-titration phase (weeks 4-20), with clinical trial data showing an average loss of 15-22% of baseline body weight by week 20

However, the natural GLP-1 has a very short half-life, lasting only 1-2 minutes in the bloodstream

Biomarkers such as fasting glucose, HbA1c, lipid panel, and blood pressure inform this assessment