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Adipose tissue serves several thermoregulatory functions: Insulation : Subcutaneous fat acts as a thermal barrier, reducing heat loss to the environment

It constitutes a fundamental biological basis underlying variability in therapeutic response and the emergence of drug resistance

This sustained action leads to a far stronger effect on appetite suppression and blood sugar control than what the body can achieve naturally, which is why these medications are highly effective treatments for type 2 diabetes and obesity

Sustained high levels of parathyroid hormone, as seen in hyperparathyroidism, stimulate osteoclasts and lead to net bone loss and hypercalcemia

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