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Subsequently, GLP-1s gained FDA approval for weight loss in 2014 (liraglutide: Saxenda/Victoza), 2021 (semaglutide: Wegovy/Ozempic/Rybelsus), and 2023 (tirzepatide: Zepbound/Mounjaro)
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The increased sympathetic tone may explain a known GLP-1RA class effect of a modest but significant increase in heart rate, the clinical consequences of which are undetermined
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