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In both models, levels of thiomethyl metabolites were low (normalised area of S-CH3-APAP-S and SO-CH3-APAP-S represent less than 3 and 1% in PHH and HRG of all detected metabolites areas, respectively) compared to direct phase II conjugates (Fig

Cyanocobalamin works but requires more metabolic conversion and releases trace cyanide (clinically insignificant at normal doses, but unnecessary when better forms exist)

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