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It has been determined that NO-mediated apoptosis is increased by p53 deficiency in VSMCs (85,86)

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177,212 Additionally, some AMPs are too cytotoxic and may have a killing effect on normal cells, but when such AMPs at low-dose are combined with chemotherapy drugs, the cytotoxicity of those AMPs can be restrained and at the same time, the anti-cancer effect of chemotherapy drugs can be significantly enhanced