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By preventing the breakdown of GLP-1 and prolonging its circulation, TEN antinociceptive action was partially counteracted by the GLP-1R antagonist exendin-3, suggesting GLP-1R-independent mechanisms

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The attachment of IgE-allergen immune complexes to FcRI activates tyrosine kinases such as Lyn, Fyn, and Syk that subsequently phosphorylate a variety of signaling molecules such as LAT, SLP-76, and PLC-1 and lead to mast cell degranulation

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Butterworth RF (2011) Neuroinflammation in acute liver failure: mechanisms and novel therapeutic targets

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