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In contrast, dichloroacetate (DCA), a pyruvate dehydrogenase kinase inhibitor, only reduced IL-6 expression but did not affect IL-8, IL-1 and COX-2 expression induced by bTNF- in bFLS (Fig

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All references to biological mechanisms are included solely for research context and should not be interpreted as claims of medical benefit

Glycemic category was determined by investigators on the basis of available information (for example, medical records, concomitant medication, and blood glucose variables) and in accordance with American Diabetes Association criteria, 30 which for prediabetes includes fasting plasma glucose levels of 100 mg/dL (5.6 mmol/L) to 125 mg/dL (6.9 mmol/L) or HbA 1c levels of 5.76.4% (3947 mmol/L), and for type 2 diabetes includes fasting plasma glucose levels of 126 mg/dL (7.0 mmol/L) or HbA 1c levels 6.5% (48 mmol/L)

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