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Neurological recovery, if present, can take longer and may not fully reverse if deficiency was severe and longstanding

Nur E, Verwijs M, de Waart DR, Schnog JJ, Otten HM, Brandjes DP, Biemond BJ, Elferink RP, CURAMA Study Group (2011) Increased efflux of oxidized glutathione (GSSG) causes glutathione depletion and potentially diminishes antioxidant defense in sickle erythrocytes

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This allows a single vial to be utilized for up to 28 days, significantly reducing medical waste

However, for multi-dose research vials, bacteriostatic water (which contains 0.9% benzyl alcohol) is required to prevent microbial contamination after the first needle puncture