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Ideally, these products should be isotonic, but hypertonic solutions (up to 600 mOsm/kg) are sometimes used to reduce injection volume, although higher osmolality can increase pain

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The results suggest that biweekly dosing with bofanglutide can produce HbA1c reductions comparable to weekly semaglutide, with the trade-off of somewhat higher gastrointestinal side effect frequency, particularly early in treatment

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