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Dose selection therefore depends on the outcome and the tolerability cost of reaching it

If you discontinue treatment without maintaining those changes, weight regain is possible

Earlier rows cover 2.5 mg at weeks 1 to 4 for initiation and tolerance assessment, and 5.0 mg at weeks 5 to 8 for an early efficacy signal and side effect monitoring

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Semaglutide generally doesnt require dose changes regardless of kidney function