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A January study published in JAMA Network Open that included 125,474 patients on the medications found that 46.5% of those with type 2 diabetes and 64.8% of those without stopped taking the drugs within one year

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Also, because GLP-1 drugs engage the brains reward circuitry the same system that governs not just craving but everyday motivation prolonged use could, in theory, dampen motivational drive in some people