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Beyond direct antioxidant activity, GSH functions as an obligatory cofactor for a family of enzyme systems that are central to cellular defence: glutathione peroxidases (GPx), which reduce peroxides and lipid hydroperoxides using GSH as the reducing substrate

70 Further research indicates that aside from inherent antimelanoma activity, NBDHEX also has the ability to enhance the function of temozolomide, with the two able to work synergistically to suppress tumor growth