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The situation changed in the late 1980s with the advent of the so-called soft ionization techniques of electrospray ionization (ESI) (Fenn et al., 1989) and matrix-assisted laser desorption/ionization (MALDI) (Clarke, 2019)

242 Astragaloside IV inhibits the PI3K/Akt/mTOR pathway by upregulating miR-155 expression, thereby preventing apoptosis and enhancing autophagy to alleviate myelin damage in Schwann cells and improve neurological function in DPN rat models

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These insulin sensitizing medications lower blood glucose and are less costly than other antidiabetic agents