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Disruption of these regulatory pathways via genetic mutations, oxidative damage, or metabolic dysregulation induces maladaptive alterations in volume regulation, membrane integrity, and ion equilibrium, ultimately hastening senescence and propelling the pathophysiology of hemolytic and vaso-occlusive conditions (25, 32, 33)
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Wang T, Feldman GM, Herlyn M, Kaufman RE
1hr in phosphate-buffered saline followed by 24 hrs in growth medium) also triggered early stress signaling pathways, including p38 MAPK activation, Hsp27 phosphorylation, and eIF2 phosphorylation
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