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For type 2 diabetes, NICE has established specific criteria for NHS-funded use, including previous treatment history and glycaemic targets

limited clinical data Management: Monitor thyroid function if symptoms of hypothyroidism develop Chemotherapy Agents: Conflicting evidence on interaction with chemotherapy Concern: Taxanes (paclitaxel, docetaxel): Some evidence suggests ALC may worsen CIPN when used during chemotherapy may consider after completion of treatment for established neuropathy Recommendation: Avoid ALC during active chemotherapy

Perez-Tilve (University of Cincinnati, USA) 67 , fed a CHD

mismatches are a hard discard signal