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cytosolic calcium instability drives mitochondrial calcium overload, destabilizes membrane potential, increases permeability transition pore opening, and amplifies ROS generation

xCT-overexpressing cancer cells depend on glucose, glutamine, and fatty acids for an energy source to acquire proliferative and survival advantages [16,17,19,68]

The principal investigator was accessible to participants via phone/text message throughout the intervention period to answer any questions that arose

Glutathione synthesis In the cell, glutathione de novo synthesis occurs in the cytosol before being pumped into mitochondria [2]

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