In the experimental study on rats with induced liver cancer, vitamin U exerted a significant antitumor effect mediated by a decrease in lipid peroxide formation, the expression level of inflammatory (TNF-) and immunoregulatory (TGF-1) cytokines, and the induction of nitric oxide synthase and glypican 3 ( The experimental study on mice have shown the positive regulation of Sult1e1 , Phlda1 , and Ciart genes in the liver with vitamin U food supplementation, suggesting that vitamin U may regulate xenobiotic, glucose, and circadian rhythm pathways ( The investigation carried out on piglet jejunal epithelial cells, IPEC-J2, treated with different concentrations of S-methylmethionine sulfonium chloride has demonstrated that vitamin U could stimulate the expression of Mucin-2 (MUC2), epidermal growth factor (EGF), glucagon-like peptide-2 (GLP-2) and insulin-like growth factor-1 (IGF-1), while inhibit the expression of transforming growth factor beta (TGF-1) in both mRNA and protein level that may great importance to repair injury and maintain the intestinal mucosa barrier, and promote intestinal development (Yang et al., 2022)

Cell 83 , 12631271 (1995)
Non-contraceptive benefits of hormonal contraceptives
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