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The glucagon component appears to preferentially direct energy expenditure toward fat oxidation rather than muscle catabolism, especially when paired with even moderate resistance training

doi: 10.1002/hep.23276 95 Vilar-GomezEMartinez-PerezYCalzadilla-BertotLTorres-GonzalezAGra-OramasBGonzalez-FabianLet al

72 noted that this risk remained constant even after adjusting for weight loss, pointing to possible mechanisms beyond weight reduction, such as changes in bile flow or direct effects on gallbladder motility due to chronic GLP-1R stimulation

Current clinical evidence suggests that starting GLP-1 therapy in gastroparesis requires careful medical evaluation and baseline gastric function assessment, not automatic exclusion from treatment

10.1113/JP272322 [DOI] [PMC free article] [PubMed] [Google Scholar] Thorens, B