Semaglutide Tirzepatide Mechanism GLP-1 only (single hormone) GLP-1 + GIP (dual hormone) Trial-average weight loss 13.7% of body weight (about 33.1 lbs) in SURMOUNT-5 20.2% of body weight (about 50.3 lbs) in SURMOUNT-5 Common side effects Nausea, constipation, reflux, usually early and fading Similar profile, sometimes stronger appetite suppression Optima pricing $249 for 10 weeks, all-inclusive $499 for 10 weeks, all-inclusive Best for Steady, proven weight loss at a lower price point The largest average reduction, if the cost fits your goals Both use the same active ingredients as the FDA-approved brand-name drugs, but Optima's compounded versions are prepared by licensed pharmacies and are not themselves FDA-approved
Taking a proactive approach can support earlier intervention, more effective treatment options and improved health outcomes
"Lower out-of-pocket drug costs in 2024 and 2025." Medicare.gov
Riley RT, Torres O, Matute J et al (2015b) Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala
However, slightly altering the chemical structure of this nutrient (adding the acetyl group), helps it work differently in the body to support both brain health and energy production.* Brain Health Acetyl L-Carnitine is structurally similar to acetylcholine and may help facilitate its production and maintenance of optimal levels
