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Additional distinguishing features include the presence of dense pigmentation, lack of maturation, nuclear pleomorphism, mitotic activity, apoptosis, lymphocytic infiltration, and a deep nested growth pattern, which are commonly evident in melanoma but not in intradermal nevi

Susan McElroy, the chief research officer at the Lindner Center of HOPE in Mason, Ohio, which provides treatment for mental and behavioral health, and a professor in the department of psychiatry and behavioral neuroscience at the University of Cincinnati College of Medicine, has herself prescribed them to patients for the condition