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[13] [12] It is important to emphasise that the observed heart rate increases are generally small and clinically insignificant for most patients

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Rather than causing a frank decrease in complex III function, this mutation appears to result in delayed assembly of the I,III,IV supercomplex, 43 thus influencing the interaction of complex III with other complexes rather than specifically affecting only complex III

As newer incretin therapies continue to emerge, clinicians will likely gain additional tools for addressing diminished response to GLP-1 medications

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