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We then treated these cells with a low dosage of erastin, the inhibitor of cysteine transporter xCT 38 , which drastically reduced GSH level and induced replication stress (Fig.7f, g)

These individuals may lose 10 lbs or more in the first month even on the lowest dose due to high genetic sensitivity to the medication. Months 23: The Steady Climb As you move up to the second and third dose strengths, the metabolic changes become more profound

doi: 10.1016/j.cmet.2019.07.013 61 KohnkeSLamBBullerSZhaoCNuzzaciDTadrossJet al

doi: 10.1016/j.fertnstert.2012.01.097, 141

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