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106 Additionally, peripheral administration of PP has been seen to decrease food intake in obese and lean rodents and ob/ob mice are not as sensitive to the peptides actions

doi: 10.1016/S0140-6736(80)90886-7 63

Preclinical studies show reduced myocardial lipid accumulation, oxidative stress, and apoptosis, with preserved mitochondrial membrane potential and calcium homeostasis ( Glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as semaglutide, enhance pyruvate entry into the TCA cycle and promote FAO, reducing lipid accumulation, preserving mitochondrial function, and attenuating cardiac remodeling in experimental models ( Other pharmacological strategies include -adrenergic receptor agonists and pan-estrogen-related receptor (ERR) agonists

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