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Although preclinical studies in colon cancer models show that IDO1 inhibition can enhance T cell infiltration when combined with antiCTLA-4 therapy (125, 126), clinical trials of IDO1 monotherapy have demonstrated limited efficacy (127), reflecting tumor-specific metabolic adaptations and compensatory mechanisms

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The citrate-isocitrate carrier SLC25A1 was not one of the 884 proteins found to be persulfidated in mouse brain (Bithi et al., 2021), but the C