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Description

Pharmacological Research 172: 105807

Oxidative Medicine and Cellular Longevity, 2016 , 3286365

Local (and systemic) estradiol can stimulate lesion production of PGE2, which can activate pain fibers, enhance neuronal invasion of lesions by stimulating production of NGF and other neurotrophins, and promote sprouting of nociceptors that contribute persistent inflammatory pain and inhibit neuronal apoptosis