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Wang S, Wei W, Ma N, Qu Y, Liu Q

Elevated levels of oxygen-derived free radicals can disrupt BBB integrity, enhance leukocytes infiltration, and directly mediate demyelination and axonal injury, thereby exacerbating autoimmune inflammation through multiple signaling pathways ( 3 Current therapies from an OS perspective Although multiple disease-modifying therapies (DMTs) are currently approved for MS, most primarily target peripheral immune activation and inflammatory cell trafficking rather than directly interrupting OS-driven injury within the CNS

Importantly, NAD+ is only one part of a complex biological system

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