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Peripheral cytokines and activated immune cells enter the CNS through a weakened BBB, increasing microglial activation, ROS generation, and neuronal death in the substantia nigra [71] (Fig

This paradox suggests that inhibiting AhR to alleviate renal injury may inevitably compromise the protective immune barrier of the intestine, thereby undermining the clinical application of the gut-kidney axis theory (73)

F., Cueto, R

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The glutathione moieties of GSSR and GSH have to interact with different protein areas as a result of the S N 2 geometry of both half-reactions of the ping pong bi-bi mechanism (Fig