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PMID: 39971407, DOI: 10.1016/j.jacc.2025.01.001

After 40 weeks, the average drop in HbA1c was about 1.7-1.9 percentage points for participants receiving retatrutide, compared with 0.8 with the placebo

Despite SNPs in genes functionally related to taste buds, also genetic variations in other genes have been shown to affect the taste perception and are likewise correlated with parameters of obesity

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It is important to note that if ED develops or worsens during GLP-1 therapy, this is more likely related to the underlying conditions being treated (diabetes, obesity, cardiovascular disease) or other concurrent factors rather than the medication itself