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A seminal in vitro study analyzed the dissolution at different medium pH of two tablet formulations (one brand and one generic) as compared to a softgel capsule ( The dissolution time of the softgel capsule preparation has been directly observed during an endoscopy session in a healthy volunteer, demonstrating that the capsule completely disappeared 21 min following its ingestion ( The better performance of softgel formulation in maintaining target TSH levels, despite a lower dose as compared to the tablet one, has been demonstrated in most of the patients bearing superficial gastritis, gastric atrophy, and resistant-to-treatment Helicobacter pylori ( The clinical efficacy of softgel formulation in a patient concomitantly treated with proton pump inhibitors has been described in a case-report ( The bioequivalence of the liquid thyroxine preparation to tablet thyroxine has been proven but, oving to the fact that the active ingredient is already dissolved, the time to reach systemic circulation is significantly shorter as compared to both tablet and softgel preparations ( H