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Preclinical studies demonstrate that DSIP can alter pain threshold responses, with observed effects that are not reversed by opioid receptor antagonists such as naloxone, suggesting involvement of non-opioid or indirect neuromodulatory pathways [7]

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Data from the Look Action for Health in Diabetes (AHEAD) Trial showed that an intensive lifestyle intervention aimed at weight loss reduced the incidence of obesity-related cancers by 16% in adults with overweight or obesity and T2D after a median follow-up of 11 years [45]