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Fabrication and evaluation of a pH-Responsive Nanocomposite-Based colonic delivery system for improving the oral efficacy of liraglutide

A representative summary of clinical trials and approved CSC-targeting agents, including pathway inhibitors, immune therapies, and metabolic modulators, is provided in Table 1

The evidence supporting these recommendations is based on case reports and retrospective data (low-quality evidence) and there remains uncertainty between the overall risks and benefits of continuing GLP-1RA and GLP-1/GIPRAs peri-procedurally

Clinical trials show average weight losses of 812% over 16 weeks, with continued loss through 6 months reaching 1215% for many patients

Differences in energy expenditure and heart weight were calculated using ANCOVA with body weight or tibia lengths as covariate using SPSS (v31)