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a , Body weight of Control, Bmal1 -KO, and Bmal1 -KO + NDI1 mice at 4 months of age on a chow diet (n = 7 Control, n = 6 Bmal1 -KO, and n = 5 Bmal1 -KO + NDI1)

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Same results were obtained on culture models, the P e values of ibuprofen were 0.28 and 0.53 10 6 cm/s across a porcine brain endothelial cell line and a rat primary brain endothelial based BBB models, respectively [71]

They also serve as metabolic branch enzymes as the GDH enzymes are involved in anapleurotic processes which regulate the flux of intermediates such as -ketoglutarate between the Krebs cycle and nitrogen metabolism [6]

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