DPP4 can cleave various peptides, leading to inactivation and/or generation of new bioactive peptides
However, with the growing evidence supporting use of particular agents in people with type 2 diabetes with specific profiles (comorbidities, overweight/obesity) and with the availability of multiple glucose-lowering agents with good efficacy and acceptable side effect profiles, the initiation of insulin can be postponed in many to later stages of the disease
GRK2 modulates GLP-1R-mediated insulin secretion in vivo In order to determine whether changes in GRK2 levels could have an effect on GLP-1R-dependent enhancement of insulin secretion in vivo, we analyzed possible differences between WT and GRK2+/ mice in the potentiation of insulin release caused by Exendin-4
Although some studies have shown an increased risk for thyroid cancer and pancreatitis in human patients, these studies are difficult to interpret due to reporting bias, lack of controlling for other patient medical histories and comorbidities, the fact that obese people are already highly at risk for specific forms of cancer and may already have primordial tumours present when beginning medication and are likely to be taking other medication apart from GLP1R agonists as well [55]
If you are already taking a GLP-1 medication, read our article on important Tips for Success While Taking Weight Loss Meds