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To explore the relevance of GSH to the distinct redox properties of FoB and MZB in vivo, we generated B cell-specific Gclc -deficient mice by crossing Gclc fl/fl mice with Mb1-Cre + mice ( Gclc fl/fl Mb1-Cre + ), in which the Cre recombinase gene is expressed under the control of the B cell-specific promoter Mb1 46
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Al-Aridi et al
The first is the operation
To keep the cycle going, another enzyme called glutathione reductase (GR) uses NADPH to convert GSSG back to GSH, creating a sustainable loop of protection
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