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During systemic inflammation, the BBB is impacted via numerous processes, such as, activation of matrix metalloproteinases (MMPs), oxidative stress and free radical damage, and direct effects of circulating cytokines on tight junction proteins

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An emerging body of evidence, including a recent umbrella review, underscores its broader potential in improving metabolic parameters, such as fasting blood glucose and insulin resistance, which are crucial in cardiovascular health (Patio-Cardona et al., 2024)