In this model, iodine deficiency and Se deficiency exacerbate H2O2 accumulation, Se deficiency decreases cellular defense, promotes thyroid cell fibrosis, increases the inflammatory response following thyroid cell necrosis, and thiocyanate overload triggers follicular cell necrosis
Histone acetyltransferases (HATs) mediate histone acetylation events that result in chromatin unwinding, whereas histone deacetylases (HDACs) result in deacetylation events that result in chromatin binding (116, 117)
In animal studies, this change inhibits detoxification, depletes glutathione levels, and increases inflammation
Guven DC, Erul E, Kaygusuz Y, Akagunduz B, Kilickap S, De Luca R, et al
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