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NAFLD-associated chronic low-grade inflammation responds to L-carnitine supplementation through reduced hepatic pro-inflammatory cytokines (e.g., IL-6), increased anti-inflammatory cytokine IL-10, and downregulation of key inflammatory pathway components (TLR4, NF-B, JNK) ( NF-B represents a master regulator of inflammatory responses in NAFLD progression
A small, protein-rich snack is often best
The clinical toxicology field should learn from the experience with hydroxychloroquine and COVID19, where early studies (animal experiments, small case series) showed promising results, which were later refuted by a robust platform trial
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