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Despite the initial belief that NEOs have low mammalian toxicity, there is growing evidence that NEOs can cause a wide range of toxic effects in animals and humans, including neurotoxicity, immunotoxicity, hepatotoxicity, nephrotoxicity, and reproductive cytotoxicity in vertebrates and invertebrates (Wang et al

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Durin, Z., Houdou, M., Legrand, D

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4.1 GSH/GSSG Regulation in Cancer, Treatment Resistance, and Ferroptosis Some cancer cells increase SLC7A11-dependent cystine uptake, GSH synthesis, NADPH production, or glutathione peroxidase activity under oxidative pressure