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Your doctor will typically recommend either: 2.5mg tirzepatide (the lowest dose) for 4 weeks, then increase 5mg tirzepatide if you tolerated semaglutide well Patients already on GLP-1 medications can often start tirzepatide at 5mg safely, though the exact starting dose should follow your provider's recommendation based on how well you tolerated semaglutide

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In addition, given the strong effects of semaglutide on glucose levels, down titrating insulin will prevent rapid decreases in glucose concentrations thereby reducing the risk of acute DRP worsening

C., Pearson, M., Eschbach, P