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[1] [2] However, longstanding neurological complications, such as peripheral neuropathy or cognitive changes, may require three to six months of consistent treatment before significant improvement occurs, and some damage may be irreversible if treatment is delayed

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Importantly, this form of plasticity can be initiated by any event that causes strong activation of a neuron, firing, and a rise of [Ca 2+ ] i to a sufficiently high level, meaning that it is capable of being engaged by almost any activity pattern that induced any of the diverse forms of homosynaptic plasticity discussed above

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