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You should see a healthcare professional if you experience any of the following: Symptoms are not improving after 10 days Symptoms get better and then suddenly get worse Difficulty breathing or shortness of breath Severe headache or sinus pain High fever above 101.3F (38.5C) Fever lasting longer than 5 days or returning after breaking Symptoms lasting more than 3 weeks You have a chronic medical condition like diabetes, heart disease, or a weakened immune system For infants, the CDC recommends seeking immediate medical attention for babies under 3 months with any fever of 100.4F (38C) or higher

doi: 10.1016/j.bpc.2010.06.003 143 PietzschJHoppmannS

Both medicines remain in active clinical development, with phase 2 and phase 3 trials ongoing

The primary strategy involves adopting a low-histamine diet , which restricts foods known to be high in histamine or that trigger histamine release

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