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Mechanism of Action Therapies acting on GLP-1R exert their effect on glucose control through multiple mechanisms based on the incretin effect that delineates the occurrence wherein oral glucose evokes a greater insulin secretion compared with intravenous glucose despite inducing similar levels of glycemia in healthy individuals

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For CJC-1295 with DAC, timing is less critical due to the extended half-life, though many researchers prefer evening administration

doi:10.1056/NEJMcp1816152 Patil SP, Ayappa IA, Caples SM, Kimoff RJ, Patel SR, Harrod CG