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Medications like semaglutide and tirzepatide can persist for days, providing sustained activation of these pathways

Although the use of targeted metabolite tracing, such as deuterium tracing of NADPH [7], is successful and remains the gold standard in the field, this approach requires mass-spectrometry, which may not be accessible to many laboratories

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Similarly, no group separation was found in the liver, with only 20 proteins induced by GLP-1GIPLani and 17 induced by GLP-1GIP (out of which 16 overlapped), and no clear pathway enrichment (Extended Data Fig

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