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AC: adenylate cyclase ADP: adenosine diphosphate AMPK: adenosine monophosphate-activated protein kinase ATP: adenosine triphosphate BAT: brown adipose tissue BCAA: branched chain amino acids cAMP: cyclic adenosine monophosphate CR: caloric restriction GCG: glucagon GIP: glucose-dependent insulinotropic polypeptide GLP-1: glucagon-like peptide-1 GLP-1RAs: glucagon-like peptide-1 receptor agonists Gs: guanine nucleotide-binding protein GTT: glucose tolerance test HSL: hormone-sensitive lipase MAPK: mitogen-activated protein kinase NE: noradrenaline PGC1: peroxisome proliferator-activated receptor gamma coactivator-1 alpha PKA: protein kinase A PPAR: peroxisome proliferator-activated receptor SAT: subcutaneous adipose tissue SIRT1: silent information regulator type 1 T2DM: type 2 diabetes mellitus UCP1: uncoupling protein 1 VAT: visceral adipose tissue WAT: white adipose tissue NT: Conceptualization, Data curation, Investigation, Resources, Visualization, Writingoriginal draft, Writingreview & editing