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The standard recommendation has been lifestyle changes, such as adopting a lower-calorie diet and increasing physical activity

Biochem Pharmacol 40: 12991305

These changes included mucosal erosion, ulcerative lesions, deformation and distortion of colonic recesses, extensive infiltration of inflammatory cells (primarily lymphocytes and neutrophils) in the mucosa and submucosa, and depletion of goblet cells

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