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In fact, due to B12s low toxicity and high upper limit, and the fact that its water soluble so we excrete whatever we dont use, the majority of studies into the side effects of B12 have been performed on the side effects of using the high strength injections, and the interactions that B12 might have with medications used to treat other conditions

NDT 14, 33293337

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While you can pre-mix a larger batch, its stability will diminish over time, even with bacteriostatic water

As a result, it has a relatively low incidence of producing drowsiness compared to clonidine (Chien et al, 1990