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Similarly, cytokines released in the brain can enter the systemic circulation and promote inflammation in the cardiovascular system, increasing the risk of CVDs

Dermatologists, plastic surgeons, and everyday users are noticing a distinct look that often accompanies success on these medications, one thats gaunt, slack, prematurely aged, and, by now, recognisable enough to have earned the nickname Ozempic Face. Dendy Engelman, MD, is one of those dermatologists: The skin appears thinner, and theres an almost deflated look to the mid-face and jawline, paired with dryness and fine lines, she says

There are theoretical concerns around hormonesensitive conditions, cancer biology, or immune effects, so Better Med Spa screens carefully, avoids use in highrisk populations, and uses conservative, cyclical dosing with medical monitoring

Moreover, sitagliptin, at doses that inhibited systemic DPP-4 activity, reduced levels of plasma apoB48, without affecting plasma apoB100 concentrations, consistent with a reduction in intestinal TRL secretion (Figure 1, E and F)