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2.13.1.6 SAMP8 mice SAMP8 (Senescence-Accelerated Mouse Prone 8) mice, a spontaneous AD model, exhibit age-related cognitive decline, oxidative damage, and impaired BBB function

Targets 5 , 477489 (2001)

Cell Stem Cell 31 , 11751186.e7 (2024)

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6.1 Glutathione metabolism: modern view of biosynthetic pathways, NADPH dependence, and relationship to thioredoxin The synthesis of glutathione (GSH) predominantly occurs through the ATP-dependent -glutamyl cycle, beginning with the action of glutamate-cysteine ligase (GCL), the key rate-limiting enzyme composed of two subunits: a catalytic component (GCLC) and a regulatory modifier (GCLM)