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The oral formulation's convenience advantage over injectable semaglutide would be even more pronounced in pediatric populations, potentially making orforglipron the preferred first-line pharmacological option for adolescent obesity if efficacy and safety data support its use

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Clinical trial data show that injectable options slightly outperform oral options for weight loss, but real-world results vary by adherence and tolerability

Nausea, vomiting, diarrhea, and constipation emerged as the most common adverse effects