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Women over 40 with a BMI of 27 or higher Those who have tried diet and exercise without sustained success Women experiencing perimenopausal or menopausal weight gain Those with weight related health conditions like prediabetes, type 2 diabetes, high blood pressure, or high cholesterol Women seeking significant rather than modest weight loss Those willing to commit to weekly injections for an extended period Women who can maintain adequate protein intake despite reduced appetite Certain conditions require caution or may preclude use

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The limitation is the delivery gap: the data underpins applied-to-skin use far more than injected use

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